I can confirm that my hosas + throttle + pedals works out of the box. I did had to enable pedals in wine configuration once though, but aside from this all works great. I’m not into customising my inputs so I can’t comment if that’s doable.

When I was moving to linux first distro I've tried was Ubuntu because of the same reasons. But in my case I didn't have a good time with it sadly, I have encountered way too many problems that noob as myself could handle. Then I got recommended Bazzite and it worked flawlessly! I was very happy with it, it worked out of the box and was rock solid and stable. I'm saying that in past tense, because now I moved to Arch, but simply because I was curious and wanted to learn linux more and not because I wasn't happy with Bazzite.