This paper covers a potential causal link between cellular senescence and various aging phenotypes. Removing senescent cells exhibiting the kinase inhibitor and senescence biomarker p16 delayed the onset of age-related phenotypes in mouse skeletal muscle, adipose, and eye tissues.

Interesting analysis on longterm trends in human life expectancy

Longevity and lifespan are a real hot topic right now. The amount of interest in the field has been increasing significantly and several labs are cranking out exciting new research. However, there is a lot of data out there and it can be tricky to interpret promising data from the noise. In response to this, a few researchers came together and put out a preprint on how to best gauge the quality of longevity interventions.

https://www.sciencedirect.com/science/article/abs/pii/S1568163724003301

They argue in favor of choosing long lived controls, in this case lab mice, as a better marker for the robustness of any longevity intervention and state…

“In the absence of independent replication, a putative mouse longevity intervention should only be considered with high confidence when control lifespans are close to 900 days or if the final lifespan of the treated group is considerably above 900 days.”

This is the 900-day rule. Now, why is this important? Many studies in longevity researc

What is Fasting and why do so many people seem to be into it?

There are many flavors of fasting, but they can be categorized into two main categories: intermittent fasting (IF) and time restricted eating (TRE). IF is defined as eating once every 24hrs and TRE is characterized by a shortened eating window, usually seen as 8hrs eating and 16hrs fasting.

IF also know as one-meal-a-day (OMAD) and TRE have been farily popular over the last few years. They gained a lot of traction, almost a decade ago, with the hope that fasting mimicking diets could help with age related declines. The overall consensus now is that this type of fasting only imparts lifespan health benefits if you also restrict total calories. However, the hype was strong and most of these dietary methods are still championed today as a way to promote health. But can they actually provide any health benefit? Well, it depends. In the scope of nutrition and health, there's no better alternative than a well balanced diet.

Hi, all!

Excited to see this community grow. Still figuring out Lemmy, so thanks for bearing with us. I want posts to have some form of identifier for ease in finding things so lets start every post with a tag before the title. Here are a few tag rules for now.

TAGS

• [QUESTION] - for posts directly asking input from the community.
• [PAPER] - for posts about specific papers
• [REVIEW] - for posts reviewing scientific literature, make sure to cite all papers discussed
• [DISCUSSION] - for a more general post around any given topic or multiple topics

FORMAT

If none of the tags seem to fit, a descriptive title will suffice.

Thanks!

This is a preprint, which means that the article has not been peer-reviewed yet. This is all part of the normal process, researchers will often present their findings before their work is published.

Here the deets!

The AgelessRx-sponsored Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) trial was a 48-week randomized, double-blind, placebo-controlled trial investigating the safety and potential efficacy of different intermittent rapamycin doses for mitigating signs of aging.

More info!

https://clinicaltrials.gov/study/NCT04488601

https://agelessrx.com/results-of-the-pearl-trial/

TLDR: wanna read a paper without the dumb publication house paywalls? Check out Sci-Hub. Don't know how to properly read scientific literature? Boom

This is mostly a PSA for the uninitiated, but you might find this useful. If nothing else I hope this is an enjoyable read to accompany you on the bus, at home, on the toilet, etc.

One of the biggest hurdles in science is access to quality literature. Unfortunately, there are many roadblocks in place that prevent people from immediate entry to this material. Some journals frequently release free copies of their publications, but for the most part you need to be connected either through the academic field or by directly paying publishing companies. Paying is bullshit. This money does not go to the authors, and honestly, many of them will gladly give you copies of their published material if you ask. But if reaching out to random authors proves