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Legendary Boons
Boons enhances Zagreus with powers from various gods.
The highest tier Legendary boons can only appear in a run if Zagreus obtained certain prerequisite boons, which makes them more elusive. All of they provide powerful combat abilities, such as giving extra cast ammo, providing a damage blocking shield, and even granting extra death defiances.
Cerberus
Despite being faked out as the boss in the Temple of Styx, Cerberus never harms Zagreus during any of his escapes from the underworld. Instead, he rests next to the throne of Hades, allowing Zagreus to pet him. He is rather attached to Zagreus, and threw tantrums which destroyed multiple places within the House of Hades when he found out about Zagreus leaving.